Significance of exosomes in COVID-19 pathogenesis and therapy

Authors

Afshar , Saeid Research Center for Molecular Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

Basiri, Parviz Research Center for Molecular Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

Ghorbanifar , Shima Dept. of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran

Keshmiri Neghab , Hoda Dept. of Photo Healing and Regeneration, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran

Mahdavinezhad , Ali Research Center for Molecular Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

Nikfarjam , Amir Hasan Dept. of Laboratory sciences, Kashan branch, Islamic Azad University, Kashan, Iran

Nobari , Sima Research Center for Molecular Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

Soheilifar , Mohammad Hasan Dept. of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran

Abstract:

Exosomes are lipid bilayer-enclosed nano-sized vesicles, which carry various biomolecules including proteins, lipids, and microRNAs. SARS-CoV-2-loaded exosomes can be entered into the susceptible host cells, and transported viral components which are associated with viral particles intercellular transmission and spread of infection. Over-stimulation of the immune system followed by excessive proinflammatory cytokine production is a hallmark of COVID-19. Mesenchymal stem cell-derived exosomes are a potential therapeutic option in COVID-19 due to their ability to decrease cytokine storm, improve tissue regeneration, and prevent multi-organs failure. Unraveling the exact role of exosomes underlying COVID-19 infection will be beneficial in understanding novel aspects of COVID-19 pathogenesis and therapy. This study aimed to investigate the importance of exosomes in COVID-19

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